Logic Projects on YouTube has a RPG they're working on that could be relevant to you.
I've tried something myself and ended up writing my own data structures to hold handles to the sprites and change them as necessary. But that's a lot of work still and not sure if it's the best long-term.
I think it'll be in development for quite some time, but Issue 2 is probably a good starting point.
The world is super fun, but a lack of specific dungeons does hurt a bit.