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Researchers isolate a pig's brain from it's body, keeping it alive and functioning for several hours
(www.popularmechanics.com)
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I guess it could already allow full body transplants for tetraplegic patients... I mean, if they have no muscle control, and get a brain-dead donor, they have nothing to lose and might live who knows how much longer.
Probably a step farther, would be spinal nerve reconstruction, or using stuff like a brain implant to reconnect to the new body. Bridging nerve gaps is one of the first goals, and Neuralink's first human tests are to be performed precisely on tetraplegic patients, so the two might be a good fit.
The article mentions an improved way to maintain blood flow to the isolated part, so that would be beneficial for all surgeries that need isolation (like heart surgery).
Of course the "pump random drugs only to the brain and see how it reacts", is also interesting, just not as sensationalist... and they could even eat the rest of the pig afterwards, if the test drugs don't make it there.
That is both fascinating and terrifying at once.