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Researchers isolate a pig's brain from it's body, keeping it alive and functioning for several hours
(www.popularmechanics.com)
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What, an eternity in a digital prison doesn't sound appealing to you?
Could be possibly better than locked-in syndrome, depending on how much your brain can interact with its surroundings. But yeah this could be the stuff nightmare is made of.
Imagine your brain triggering a phantom itch but you having no limbs to scratch with.