MX, ThinkPad t480, intel+Nvidia (no matter which drivers): close screen to suspend causes it, and it's not happening in other DE's. Can't be bothered to try out xfce on another distro just to confirm. I made a post when I was trying to fix it for myself.
The final straw were the Bluetooth headphones though. Most of the time I'd have to manually select them 20 times as the output device so it sticks, and then it'd switch back to the speakers as soon as the call starts. Or I'd hear the other person through the correct device, but the they couldn't hear me on Skype, but could on Google meet.
MX was pretty reliable otherwise.
MX (Debian + Nvidia + tools to make use easier).
Install OBS and other software from flatpak