I wanted to do the same to my house but never went through with it due to time, expense and my health.
Biggest issue I had to deal with immediately was ventilation and keeping the air clean.
Second issue was noise.
I was going to insulate the ceiling not for heating but for sound proofing and that led to thinking of sealing and keeping the free air in the basement. After that was going considering how to circulate and maintain air in the basement and away from the living area upstairs.