I'm pretty positive my parents haven't grout sealed their shower since they bought their house, so it's been at least, oh..... 27 years for them?
I mean, not that I recommend going this long, as now as their dutiful and caring adult child I'll likely be the one taking it upon myself to completely regrout the whole thing, but goes to show how long you could go with things probably being mostly okay.
I reckon it'd depend significantly on the instance. Beehaw has a signup form reviewed by humans - measures like this are by no means perfect, but coupled with other bot detection software could help. If an instance developed a real issue with bots, other more strict instances could potentially ban up votes and comments from accounts on it.
At the very least, tracking instances that account interaction came from should be quite doable, so users part of more strict instances could filter out upvotes and comments from less strict instances if desired.