I like to see just one successful experiment with closed ecological systems on earth before even thinking of doing it in space with artificial gravity.
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I think all attempts to design a closed ecological system (on or off Earth) are likely to fail due to Gall's Law.
Instead, I think space habitats are going to gradually increase in autonomy from Earth over many iterations.
Another huge issue not mentioned here is radiation. There would have to be significant shielding (without some other future tech) that would just add to an already huge engineering undertaking.
Inyalowda bera wanya fo du beltalowda depend ere ereluf unte owkwa fong earth, sasa ke?