Okay - some weirder takes here but hear me out. I’d love to see a science-vessel focused on anomaly of the week style episodic writing, with moral and ethical quandaries and personal growth and a search for “the meaning of it all” trumping action, adventure, and universe saving.
Accordingly, I’d want that science vessel to be home to a delightfully nerdy crew of pedants, malcontents and misfits, all seeking something outside of the boring federation life or more militaristic vessels.
The list of people that would be amazing to Star or guest:
Neil Patrick Harris as captain
Felicia day as chief science officer.
Aubrey Plaza on tactical, way too smart and capable for her own good (and sardonic style)
William Jackson Harper (Chidi from The Good Place) as first officer
Warwick Davis as chief engineer, with awesome fully custom/adaptive AR controls and a combo of old-man wit and crazy ideas that gets them in and out of jams
With guest turns from David Hyde Pierce (Niles from Frazier), Kristen Bell, Ted Danson, Donald Glover, etc
Just go full nerd with it like discovery tried to, but without the constant intrigue and epic action. Let them be a family growing together and finding a place where they belong, puzzling through each new chapter together. TNG but for 2023 instead of 1988.