I had one Linux server that was up for over 500 days. It would have been up longer but I was organizing some cables and accidentally unplugged it.
Where I worked as a developer we had Sun Solaris servers as desktops to do my dev work on. I would just leave it on even during the weekends and vacations, it also had our backup webserver on it so we just let to run 100%. One day the sys admin said you may want to reboot your computer, it's been over 600 days. π I guess he didn't have to reboot after patching all that time and I didn't have any issues with it.