Not in the way that Windows does, at that point your best bet is SysRq+REISUB or SSH in and kill kwin and possibly issue a manual reset in /sys. But even if successful, half your apps will have died as Wayland compositor handover isn't quite reliable yet.
I also believe if the GPU hangs the kernel already tries a reset, I would start with a manual reset via SSH to confirm it's even worth pursuing and then you can figure out a hotkey situation. Even if the GUI is locked up, you can listen to evdev devices and catch an arbitrary keyboard shortcut and run a shell script that resets the system to your liking.