I really like the GUI in Pop!_OS. It's a custom GNOME installation with some sort of window tiling manager I don't know what it's called. I really like it, and I like their system themes, too. It's very macOS-like. Simple, clean, and functional with a lot of little custom tweaks put in by system76 to cover some gaps in GNOME's basic configuration and things that are missing from Ubuntu (Pop!_OS is an Ubuntu variant).
Others have mentioned Linus Mint with Cinnamon. I haven't used it in several years, but I recall it being very nice and simple. It's very Windows-like, which I'm not a fan of, but the interface was quite pretty, as I recall.